Brattleboro, VT (October 8, 2003) – A human clinical study published in the Medline indexed, peer-reviewed Journal of Pharmacy and Pharmacology (JPP) in June, 2003 offers promising evidence of antioxidant protection from the carcinogenic effects of smoke and environmental toxins through the Supercritical Antioxidants™ herbal formulation. All subjects in the clinical trial with elevated levels of cancer-causing chemicals in their systems were restored to normal within one month. Supercritical Antioxidants, manufactured by New Chapter, Inc, of Brattleboro, Vermont is a turmeric-based herbal formulation that helps inhibit the body's formation of carcinogens caused by environmental smoke and toxins. The formula was found to activate the liver’s ability to detoxify oxygen free radicals and eliminate them from the body via Phase I and Phase II pathways.

Whenever a person inhales smoke or dines on a charbroiled (well-smoked) steak, the body is flooded with the carcinogen, benzo(a)pyrene, a large, heavy molecule that literally sinks to the bottom of tissues and organs.

To eliminate this noxious chemical and oxygen free radicals like it, the liver’s detoxification function must be capable of heavy lifting. However, with the presence of so many toxins in food, water, air and our living environment, the liver is often overtaxed and incapable of effectively eliminating the toxic load from the system. The result is that impurities accumulate, weaken the system, and ultimately morph into definable illnesses or chronic conditions. This is especially true for long-term smokers like the subjects in the study.

As the research shows, Supercritical Antioxidants stimulates the up-regulation of ALAT (Alanine Aminotransferase), Cytochrome P450, Glutathione Reductase, and SOD (Superoxide Dismutase), critical to both Phase I and Phase II pathways of elimination for the liver. Supercritical Antioxidants was found to scavenge free radicals on the cellular level and then jettison them through the urinary system (Phase I pathway) and the colon (Phase II pathway).

The Supercritical Antioxidants study was conducted by researchers from the Amala Cancer Research Centre and the Industrial Toxicology Research Center in India. They found the liver’s natural detoxification capability to be dramatically enhanced by administering one capsule of the herbal antioxidant formula twice daily for a month. The research consisted of human clinical, animal clinical and in vitro trials. The human clinical portion measured the anti-mutagenic effects of Supercritical Antioxidants on 45 smokers, aged 30-40, all of whom had been smoking for at least 10 years. The study was entitled “Antimutagenicity of Herbal Detoxification Formula Smokeshield Against Environmental Mutagens.”

The herbal extracts comprising Supercritical Antioxidants are from herbs in long use in traditional medicine and considered safe for daily human consumption. Turmeric (Curcuma longa), the second-most researched herbal root in the world, has been used on a daily basis by billions of people for thousands of years. Green tea is consumed on a daily basis throughout Japan and China, and rosemary, parsley, ginger (the single most researched root), clove, and parsley are spices in common usage worldwide. The turmeric extract used in Supercritical Antioxidants is a dual extract, combining a supercritical (CO2) and a hydroethanolic extract, which together were described by the researchers as a "broad spectrum extract that is highly concentrated, chemical-solvent free, undamaged by heat or chemical stress, and rich with all the healing and protective turmeric oils, resins, and curcuminoids." The researchers explained that, "this turmeric extract is provided with other herbs that have demonstrated profound synergy with turmeric, multiplying the power of this most important herb by several fold." The supercritical extraction of turmeric and other herbs used by New Chapter is done in a pharmaceutical-grade laboratory in Germany operating in compliance with strict government standards.

R.C. Srimal, MD, renowned for his groundbreaking research in the 1960s on the anti-inflammatory properties of turmeric concluded, "As a research MD, I have been studying the medical uses of turmeric for over 35 years. It is perhaps one of the most powerful herbal responses to a wide range of medical needs. I have no hesitation in recommending New Chapter's supercritical turmeric extract, which I consider the premier turmeric extract in the world. It preserves the full spectrum of all turmeric's important healing properties including the essential oils."

New Chapter, Inc. of Brattleboro, Vermont, manufactures Supercritical Antioxidants and 70 other formulations. For more information on the study and New Chapter, Inc., please contact Dean Draznin Communications: Dean Draznin 641-472-2257 dean@drazninpr.com or Cynthia Terpstra 561-445-8715 cynthia@drazninpr.com.

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About the Researchers

Dr. Ramadassan Kuttan, Ph.D., is Research Director of the Amala Cancer Research Centre in India. He has published nearly 100 papers in leading medical journals around the world and has specialized in research on the medicinal effects of curcumin (from turmeric) and catechin (from green tea).

R.C. Srimal, MD, is considered the father of research on the medical benefits of turmeric. His groundbreaking research in the 1960s opened the door to extensive serious laboratory and clinical documentation of turmeric's anti-inflammatory health benefits. Dr. Srimal has published over 100 research studies in leading pharmacology journals over the past 40 years.

About Supercritical Antioxidants Herbal Formulation

Supercritical Antioxidants is a patent-pending formula consisting of supercritical and other chemical-solvent free extracts of turmeric, green tea, rosemary, parsley leaf, ginger, peppermint and clove -- all potency assured for key marker molecules. A University of Indiana School of Medicine 1999 study shows green tea supports DNA integrity and decreases smoker's free radical generation. Research at Rutgers and Michigan State Universities demonstrate that rosemary's free radical scavengers are capable of enhancing multiple detoxification enzymes while countering even the compounds produced in frying food. According to published work in the medical journal Carcinogenesis, peppermint helps counter a problematic smoke component called benzo[a]pyrene. According to U.S. Department of Agriculture database, clove is the richest known source of the phytonutrient eugenol, one of nature's most powerful free radical scavengers supporting cardiovascular health.

About the Journal of Pharmacy and Pharmacology (JPP)

The Journal of Pharmacy and Pharmacology, edited by Professors Duncan Craig and David Jones, both at the School of Pharmacy, The Queen's University of Belfast, is a publication of the Royal Pharmaceutical Society of Great Britain. The Journal is a monthly record of new work in the international pharmaceutical sciences, which is read world-wide and indexed on MedLine. http://jpp.pharmpress.com/content/html/index.htm

For more information on this research, please contact Dean Draznin Communications, 641-472-2257 or 561-445-8715.